2017 GIRF Grants

$21,000
Jun Miyoshi, “Is antibiotic exposure in early life a risk factor for the development of Inflammatory Bowel Diseases?”
Mentor: Eugene B. Chang
Awarded: $7,000

Sonali Paul, “Patient and Provider Attitudes Towards the Use of Organs from Hepatitis C Positive Donors in the ERA of Direct Acting Antiviral Therapy”
Mentor: Elbert Huang
Awarded: $7,000

Ashley Sidebottom-Wilkinson, “Exploitation of Commensal Gut Bacteria as Route to Chronic Inflammation by Antimicrobial Peptide Resistance”
Mentor: Dionysios Antonopoulos
Awarded: $7,000

2013 GIRF Grants

$40,000
Christopher Chapman, “Epigentic DNA Modifications in Inflammatory Bowel Disease”
Mentor: John Kwon
Amount Requested: $15,000
Awarded: $10,000

Karen Edelblum, “Communication between yintraepithelial lymphocytes and epithelial cells in preventing bacterial infection”
Mentor: Jerrold Turner
Amount Requested: $15,000
Awarded: $10,000

Stacy Kahn, “Development of tolerability questionnaire for fecal microbiota transplantation”
Mentor: David Rubin
Amount Requested: $6,200
Awarded: $3,000

Tiffany Patton, “Identification of the esophageal microbiome in eosinophilic esophagitis”
Mentor: Cathryn Nagler
Amount Requested: $15,000
Awarded: $5,000

Diana Ringus, “Characterization of the human gut virome of inflammatory bowel disease”
Mentor: Eugene Chang
Amount Requested: $15,000
Awarded: $12,000

2012 GIRF Grants

$57,000
Emanuelle Bellaguarda, “The effect of conjugated linoleic acid on gastrointestinal microbiota of healthy individuals and patients with mild Crohn’s disease.”
Awarded $15,000

Christopher Chapman, “Epigentic DNA Modifications in Severe Ulcerative Colitis.”
Awarded $10,000

Valentina Discepolo, “Creation of a novel mouse model to study the role of viruses in inflammatory bowel disease.”
Awarded $10,000

Stephen Murphy, “Generation of the GIRF-ATG16L1 lymphocyte cell panel: role of iron in Crohn’s disease.”
Awarded $12,000

Fangming Tang, “TLR2/6 and TLR2/1 At the intersection of immune regulation and intestinal inflammation.”
Awarded $10,000

2011 GIRF Grants

$35,000
Sushila Dalal, “Microbial regulation of intestinal gene expression through small RNA molecules (microRNA).”
Awarded $10,000

Frank Hoentjen, “Predicting a subsequent diagnosis of Crohn’s disease in ulcerative colitis patients undergoing colectomy and ileo pouch-anal anastomosis using genetic profiling.”
Awarded $9,000,

Shirley Paski, “Do epigenetic mechanisms regulate celiac disease?”
Awarded $9,000

Vanessa Leone, “The effect of dietary conjugated linoleic acid on the gut microbiome in the setting of inflammatory bowel disease.”
Awarded $6,000

Adam Stein, “Pilot Study: Survey of Marijuana Use in Patients with Inflammatory Bowel Disease.”
Awarded $500

Adam Kaufman, “Sexual Function in a United States Tertiary Care Inflammatory Bowel Crohn’s Population.”
Awarded $500

2010 GIRF Grants

$35,000
Stacy Kahn, Instructor, Pediatric Gastroenterology, “Bacteriotherapy, a novel treatment for ulcerative colitis, exploring patient interests & concerns” Mentor: Dr. David Rubin.
Awarded: $12,500

Hongyan Zhu, Research Associate, “The Inhibitory Role of Vitamin D Receptor in Development of Inflammatory Bowel Disease.”
Awarded: $10,000.

Sushila Dalal, “Microbial regulation of intestinal gene expression through small RNA molecules (microRNA).”
Awarded: $12,500.

2009 GIRF Grants

$19,000
Nancy McGreal, “Heritable Risk of Inflammatory Bowel Disease in Multiplex Families in the Pediatric Inflammatory Bowel Disease Consortium.”
Awarded: $6750

Shirely Paski, “Development of a Mouse Model to Study Intestinal Permeability.”
Awarded $10,000

Lesley Rhee, The Role of ATG16L1 and Autophagy in Crohn’s Disease.” Awarded:  $3250

Henit Yanai, Clostridium Difficile Prevalence as part of the Microbiota of IBD Patients and the General Population.”
Awarded: $4000,

Timothy Zisman,” Predictors of Response to Infliximab and Cyclosporine in Hospitalized Patients with Severe Steroid-Refractory Ulcerative Colitis.”
Awarded: $1000

2008 GIRF Grants

$40,500
Vani Konda: “Using Combined Chromoendoscopy with Acetic Acid and Digital Technology to Detect Dysplasia and Neoplasia in Barrett’s Esophagus.”
Awarded $4,500.

Joel Pekow, “MicroRNA gene expression profile in epithelium of patients with ulcerative colitis.”
Awarded: $12,000

Nanda Venu, “MicroRNA in inflammatory and sporadic colon cancer.”
Awarded $12,000

Yunwei Wang, “Role of intestinal microbiota and host immune response in causing IBD.”
Awarded $12,000

2007 GIRF Grants

$41,500
Shein Hu, “MicroRNA: a New Generation of Anti-Inflammatory and Anti-Cancer Agents for IBD and IBD-Associated Colon Cancer.”
Awarded $7,500

Yan Li, PhD, “Examination of VDR Expression in Human IBD Specimen.”
Awarded $15,000

Gautham Reddy, MD, “A Pilot Trial to Determine the Safety and Efficacy of Fluvastatin in Previous Partial Responders to Pegylated Interferon and Ribivirin in Patients with Genotype 1 Hepatitis C.”
Awarded $14,000

David Rubin, MD, “Pilot Study to Determine the Feasibility of Correlating Colonic Optical Coherence Tomography Findings in Histological Grades of Inflammation in Ulcerative Colitis.”
Awarded $7,500

Wallene Yang, MD, “Effects of Lactulose Treatment for Hepatic Encephalopathy on Colonic Microflora.”
Awarded $7,500.

2006 GIRF Grants

$75,308.60
Russell Cohen, “Azathioprine and NRH in Inflammatory Bowel Disease.”
Awarded $750

Stacy Kahn, “Alternative Treatment for Acute Childhood Diarrhea.”
Awarded $7,500 and an additional $7,500 to be granted upon Dr. Kahn’s successful infection of cells with Rotavirus, Growth of Lactobacillus GG, with the plan to treat the Rotavirus-infected cells with the Lactobaccillus.

Rajesh Keswani, “Multiband Imaging Colonoscopy in Colitis Surveillance.”
Awarded $7,500.

Yan Chun Li, “Preventive Role of VDR in Pathogenesis of Inflammatory Bowel Disease.”
Awarded $12,500

James Lodolce, “Creation of a Novel Mouse Model of Inflammatory Bowel Disease.”
Awarded $10,000 and additional $5,000 to be granted upon your achieving them into the mouse blastocysts.

Andrew Ross, “EMR for the Treatment of Barrett’s Esophagus with Dysplasia and Early Cancer.”
Awarded $7,500

David Rubin, “Gastro-Intestinal Research Foundation Associate IBD Endoscopy Database Ongoing Management and Support.”
Awarded $17,058.60

2005 GIRF Grants

$53,100
Laura Harrell, “Acute Phase Proteins and their Role in Predicting Response to Remicade Therapy.”
Awarded $12,000

Sunanda Kane, “The Relationship between Homocysteine Levels in Pregnancy and Low Birth Weight in Mothers with Inflammatory Bowel Disease.”
Awarded $1,700

Raj Keswani, “Incidence of Celiac Disease in Patients with Severe Malabsorption Due to Short Bowel Syndrome.”
Awarded $1,000

Jeffery Nathanson, “Biomarkers to Predict Dysplasia or Colon Cancer in Ulcerative Colitis.”
Awarded $12,000

Andrew Ross, “A Prospective Analysis of Video Capsule Endoscopy in Combination with Push-Pull Enteroscopy using the Double Balloon Technique in the Diagnosis and Treatment of Obscure and Gastrointestinal Bleeding.”
Awarded $12,000

David Rubin, “Development of an Endoscopy Database for IBD.”
Awarded $14,400

2003-2004 GIRF Grants

$41,500
Mae Ciancio, “To Charaterize the Expression and Potential Role of Inducible Heat Shock Proteins in Inflammatory Bowel Disease and Experimental Colitis.”
Awarded $15,000

Greg Cohen, “Effect of Actigall on Ulcerative Colitis Associated Colon Cancer.”
Awarded $15,000

Timothy Kinney, “Focal Gastritis to Discriminate between Crohn’s Disease and Ulcerative Colitis.”
Awarded $7,500

Jeffery Tuvlin, “The Development of Treatment Guidelines for Physicians Treating Patients with Inflammatory Bowel Disease Who Develop Pyoderma Gangrenosum Next to Their Colostomies or Illeostomies.”
Awarded $4,000

The Associate Board awarded $2,500 to the gastroenterology clinic to fund a new computer for all the fellows to use.

2002 GIRF Grants

$40,000
Denise Bonen, PhD, Research Associate/Assistant Professor, “The Effects of the Expression of Mutant forms of the Nod2 Gene in Human Monocytes.
Awarded $15,000

Greg Cohen, MD, Cox-2 and iNOS Expression in Aberrant Crypt Foci fromHuman Colons.”
Awarded $15,000

Nina Merel, MD, “Genetic Defects in Pre-Cancerous Flat and Depressed Colorectal Lesions.”
Awarded $10,000

2001 GIRF Grants

$25,000
Mark Ropeleski, MD, Post-Doctoral Research Fellow, “Intestinal Cytoprotection and Wound Healing: the Delineation of Signaling Pathways Involved in Interleukin-ll Stimulated Hsp25 Expression.
Awarded: $12,000

David Rubin, MD and Nini Merel, MD, Fellows, “Do Patients Understand Why They Undergo Endoscopic Procedures?”
Awarded $5,000

Amit Shah, MD, Fellow, “Evaluation of a New Antral Mucosal Peptide in Gastrointestinal Tissue”
Awarded $8,000

1999-2000 GIRF Grants

$25,000
Hari Conjeevaram, MD, Assistant Professor of Medicine, “Epidemiology of Risk Factors and Assessment of Liver Injury in Hepatitis C Virus Antibody Positive, RNA Negative Individuals.”
Awarded $5,000

Eli Ehrenpreis, MD, Assistant Professor of Clinical Medicine, “A Radomized, Placebo Controlled Trial of Thalidomide Therapy in Patients with Crohn’s Disease.”
Awarded: $10,000

Loren Joseph, MD, Associate Professor of Clinical Medicine, “Identification of Biomarkers for Cancer Risk Assessment by Microarray Analysis.”
Awarded $10,000

1998 GIRF Grants

Clara Abraham, MD, Fellow in Gastroenterology, “The Role of LFA-1 in T-Cell Activation.” Dr. Abraham’s project involves a study of T lymphocytes which are regulatory cells of the immune system.  The LFA-1 plays a significant role in “bringing” T-cells to the site of disease.  This project will involve DNA technology and microscopy.

David Boone, PhD, Postdoctoral Fellow, “Finding the Cause of Ulcerative Colitis.” Dr. Boone’s project involves study of laboratory mice that have had the gene for interleukin-2 removed.  The study of specific gene deletions that result in ulcerative colitis in mice, will help to determine the cause of this disease in humans.  Dr. Boone’s project is associated with the exciting work of Dr. Averil Ma.

Russell Cohen, MD, Assistant Professor of Clinical Medicine, “A Comparison of Health Care Outcomes in Patients with Inflammatory Bowel Disease Managed by Primary Care Physician Specialists.”  Dr. Cohen hopes to prove that sending patients to the appropriate specialist early in the management and care of the disease will provide a superior outcome for the patient’s quality of life.  The insurance companies and HMO’s must see these facts on paper to justify and early referral to a specialist.

Eli Ehrenpreis, MD, Assistant Professor of Clinical Medicine, “An Open Label Trial of Thalidomide in Refractory Cohn’s Disease.” Dr. Ehrenpreis’ project will follow 20 patients with refractory Crohn’s disease, and how the drug, Thalidomide has an effect on the disease.  The study has been approved by the FDA and University of Chicago.

Sunanda Kane, MD, Fellow in Gastroenterology, “Genetic Testing and Counseling for Colon Cancer.” Dr. Kane’s project will rest blood samples for genetic testing/screening of colon cancer.  Until now people who sought this type of testing would have only been able to go to Johns Hopkins or the Mayo Clinic.  This project will be a tremendous springboard for the University of Chicago Hospital, linking Dr. Kane’s results with Johns Hopkins through a networked database.

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